Discovery of new chiral sulfonamides bearing benzoxadiazole as HIF inhibitors for non-small cell lung cancer therapy: design, microwave-assisted synthesis, binding affinity, in vitro antitumoral activities and in silico studies

Autor:	Demet Taşdemir Kahraman, Ayşegül Karaküçük-İyidoğan, Yasemin Saygideger, Emine Elçin Oruç-Emre, Tugba Taskin-Tok, Eyüp Başaran, Sedat İlhan, Burcu Saygıdeğer Demir, Aykut Üren, Hasan Bayram
Rok vydání:	2022
Předmět:	Materials Chemistry General Chemistry respiratory system Catalysis
Zdroj:	New Journal of Chemistry. 46:2777-2791
ISSN:	1369-9261 1144-0546
DOI:	10.1039/d1nj03809e
Popis:	Thirty-four chiral compounds having benzoxadiazole and sulfonamide moieties on the skeleton have been synthesized. The in vitro cytotoxic activity and apoptotic effects of these compounds have been evaluated using the A549 lung cancer cell line.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a4b0543454f3803ebfe45225c1b4909b https://doi.org/10.1039/d1nj03809e Zobrazit plný text záznamu