Variations in the genes encoding the peroxisome proliferator-activated receptors ? and ? in psoriasis
| Autor: | Kristian Reich, Christine Neumann, Philipp Matern, Rotraut Mössner, Ullrich Krüger, Jürgen Brockmöller, Rolf Kaiser, Inke R. König, Andreas Ziegler, Götz A. Westphal |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty Alpha (ethology) Peroxisome proliferator-activated receptor Inflammation Dermatology General Medicine Biology medicine.disease Endocrinology medicine.anatomical_structure Nuclear receptor chemistry Internal medicine Psoriasis medicine lipids (amino acids peptides and proteins) medicine.symptom Receptor Keratinocyte Transcription factor |
| Zdroj: | Archives of Dermatological Research. 296 |
| ISSN: | 1432-069X 0340-3696 |
| Popis: | The three peroxisome proliferator-activated receptor (PPAR) subtypes alpha, delta (beta), and gamma belong to the group of nuclear receptors that act as ligand-activated transcription factors. Recently, expression of PPAR alpha and gamma in keratinocytes has been demonstrated, and ligands of PPAR alpha and gamma have been found to enhance epidermal maturation and protect against cutaneous inflammation. There is evidence for a possible role of PPARs in psoriasis, as the expression of PPAR alpha and gamma is decreased in lesional skin and treatment with PPAR gamma agonists improves psoriatic keratinocyte pathology in vitro and in vivo. We performed a case-control study to search for possible associations between variations in the genes encoding PPAR alpha and gamma and psoriasis. Seven variations in these genes were analyzed in 192 patients with chronic plaque-type psoriasis and 330 healthy controls by PCR-based methods. No association between any of the investigated PPAR variants and psoriasis was found. Our findings argue against a significant contribution of the investigated PPAR variations to the genetic basis of psoriasis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink