Stereoselective total synthesis of (2S,3R)-3-hydroxypipecolic acid
Autor: | Won-Hun Ham, Yong-Shou Tian, Van-Thoai Pham, Chang-Young Oh, Jae-Eun Joo, Yun-Sung Chung, Kee-Young Lee |
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Rok vydání: | 2008 |
Předmět: | |
Zdroj: | Tetrahedron: Asymmetry. 19:318-321 |
ISSN: | 0957-4166 |
Popis: | A concise, stereocontrolled synthesis of (2 S ,3 R )-3-hydroxypipecolic acid 1 is described. Key features involve diastereoselective oxazoline formation catalyzed by palladium(0) and intramolecular cyclization by catalytic hydrogenation of an oxazoline. |
Databáze: | OpenAIRE |
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