Involvement of tyrosine and phosphatidylinositol kinases in oxidized glutathione and glutoxim regulation of Na+ transport in frog skin

Autor:	S. N. Butov, V. G. Antonov, O. E. Lebedev, Z. I. Krutetskaya, A. V. Melnitskaya
Rok vydání:	2010
Předmět:	integumentary system Kinase medicine.drug_class Cell Biology Biology Tyrosine-kinase inhibitor Receptor tyrosine kinase Cell biology Wortmannin chemistry.chemical_compound Insulin receptor Biochemistry chemistry medicine biology.protein Phosphatidylinositol Tyrosine Tyrosine kinase
Zdroj:	Cell and Tissue Biology. 4:273-279
ISSN:	1990-5203 1990-519X
DOI:	10.1134/s1990519x10030090
Popis:	The role of tyrosine and phosphatidylinositol kinases in oxidized glutathione (GSSG) and its pharmacological analogue, glutoxim, regulation of Na+ transport in Rana temporaria frog skin was investigated by the voltage-clamp technique. It was shown for the first time that the preincubation of the skin with tyrosine kinase inhibitor genistein or with two structurally distinct phosphatidylinositol kinase inhibitors, wortmannin and LY294002, significantly decreased the stimulatory effect of GSSG or glutoxim on Na+ transport. The data suggest that GSSG and glutoxim can transactivate insulin receptor in the basolateral membrane of epithelial cells and trigger the signaling cascade, which involves tyrosine and phosphatidylinositol kinases, which stimulates Na+ transport in frog skin.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a498ad6a6e5dceccfa89ee3cb1f90d90 https://doi.org/10.1134/s1990519x10030090 Zobrazit plný text záznamu Full text from SpringerLink