A phosphorus-containing chiral amidine ligand for asymmetric reactions: enantioselective Pd-catalyzed allylic alkylation

Autor:	Kazuo Achiwa, Toshiaki Morimoto, Akihito Saitoh
Rok vydání:	1997
Předmět:	Stereochemistry Ligand Organic Chemistry Enantioselective synthesis Asymmetric induction Dimethyl malonate Catalysis Inorganic Chemistry Amidine chemistry.chemical_compound Tsuji–Trost reaction chemistry Nucleophile Physical and Theoretical Chemistry
Zdroj:	Tetrahedron: Asymmetry. 8:3567-3570
ISSN:	0957-4166
Popis:	Phosphorus-containing amidine 7 was prepared through several steps from L -valine 1 . The new ligand for asymmetric reactions was evaluated in the palladium-catalyzed allylic alkylation of 1,3-diphenylprop-2-enyl acetate and pivalate 8a,b with the nucleophile derived from dimethyl malonate as a preliminary study. Excellent levels of asymmetric induction up to 95% e.e. were achieved along with an efficient conversion.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a4895b38b6df174d01ab8f64c3559dae https://doi.org/10.1016/s0957-4166(97)00482-5 Zobrazit plný text záznamu Full Text from ScienceDirect