Study of induced amplification of antibacterial activity of ciprofloxacin on coupling with ZnO nanoparticles (ZnONp)
| Autor: | Asma M. Tatagar, Javed I. Moodi, M.A. Phaniband, Jyothi C. Abbar, Preeti Kulkarni |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
010302 applied physics
biology Chemistry medicine.drug_class Antibiotics Pseudomonas Nanoparticle 02 engineering and technology Antibacterial effect 021001 nanoscience & nanotechnology biology.organism_classification Antimicrobial 01 natural sciences Microbiology Ciprofloxacin Zno nanoparticles 0103 physical sciences medicine 0210 nano-technology Antibacterial activity medicine.drug |
| Zdroj: | Materials Today: Proceedings. 49:632-637 |
| ISSN: | 2214-7853 |
| DOI: | 10.1016/j.matpr.2021.05.157 |
| Popis: | The gradual rise in the resistivity of bacterial strains towards the broad-spectrum antibiotics is alarming and pretence an urgent threat to mankind in the near future. Advanced strategies are a necessity to combat this issue in order to reduce the mortality as well as infection rates. One of the possible routes to address the antibiotic resistivity of bacterial strains is to amplify the effect of antibiotics. Zinc oxide nanoparticles (ZnONp) are able-bodied antimicrobial agents that are regarded as non-hazardous and bio-friendly. Herein we describe in our study the successful synthesis and characterization of ZnONp, followed by the induced amplification of the antibacterial activity of Ciprofloxacin by coupling with Synthesized ZnONp. The synthesized Zinc Oxide Nanoparticles (ZnONp) were characterized using XRD and FE-SEM studies. The particle size of ZnONp was found to be 25–70 nm. The present study aims to investigate the antibacterial effect of synthesised ZnONp against the bacterial strains of S. aureus, E. coli, Pseudomonas and S. mutans as well as the study aims to analyse the amplification of the antibacterial activity of Ciprofloxacin on coupling with Synthesized ZnONp. The Disc diffusion technique was used to determine the antibacterial activity of ZnONp, Ciprofloxacin and ZnONp-Ciprofloxacin couple against the bacterial strains. The results indicated that the ZnO nano particles potentiate bactericidal efficacy of ciprofloxacin antibiotics. |
| Databáze: | OpenAIRE |
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