Signal antonymy unique to myelodysplastic marrows correlates with altered expression of E2F1
| Autor: | Stephanie A. Gregory, La Tanya Broady-Robinson, Azra Raza, Bruce Dangerfield, B. Yifwayimare Mativi, Parameswaran Venugopal, Harvey D. Preisler, Suneel D. Mundle, Biarou Li, Jonathan D. Cartlidge, Vilasini Shetty |
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| Rok vydání: | 2000 |
| Předmět: |
Pathology
medicine.medical_specialty Retinoblastoma Myelodysplastic syndromes Hematology Biology medicine.disease Peripheral blood mononuclear cell Head and neck squamous-cell carcinoma Lymphoma medicine.anatomical_structure Apoptosis hemic and lymphatic diseases medicine Cancer research E2F1 Bone marrow |
| Zdroj: | British Journal of Haematology. 109:376-381 |
| ISSN: | 0007-1048 |
| Popis: | Myelodysplastic syndromes (MDS) have previously been reported to show competitively high rates of apoptosis and proliferation in the bone marrow (BM). Using a double-labelling technique in the present study, we demonstrated that a significantly high number of S-phase cells were simultaneously apoptotic (signal antonymy; SA) in MDS (mean ± s.e.m. 53·5 ± 6·7%, n = 24, P |
| Databáze: | OpenAIRE |
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