Dirhodium-Catalyzed Chemo- and Site-Selective C–H Amidation of N,N-Dialkylanilines

Autor:	Kenta Arai, Kazuhiro Morisaki, Gong Chen, Takeo Kawabata, Yoshihiro Ueda
Rok vydání:	2020
Předmět:	010405 organic chemistry Site selectivity Nitrene Organic Chemistry 010402 general chemistry Ring (chemistry) 01 natural sciences Medicinal chemistry 0104 chemical sciences Catalysis chemistry.chemical_compound Aniline chemistry Nitrogen atom Group (periodic table) Site selective
Zdroj:	Synlett. 32:728-732
ISSN:	1437-2096 0936-5214
DOI:	10.1055/a-1334-6450
Popis:	A method for dirhodium-catalyzed C(sp3)–H amidation of N,N-dimethylanilines was developed. Chemoselective C(sp3)–H amidation of N-methyl group proceeded exclusively in the presence of C(sp2)–H bonds of the electron-rich aromatic ring. Site-selective C(sp3)–H amidation proceeded exclusively at the N-methyl group of N-methyl-N-alkylaniline derivatives with secondary, tertiary, and benzylic C(sp3)–H bonds α to a nitrogen atom.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a46ee55892cf51f8d7cfee595a9f5fd5 https://doi.org/10.1055/a-1334-6450 Zobrazit plný text záznamu