Autor: |
Giorgio Annoni, Ludovica Caputo, Jacopo Tagliabue, Carlo Vergani, Anthony Ryan |
Rok vydání: |
1998 |
Předmět: |
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Zdroj: |
Recent Advances in Geriatrics ISBN: 9781489914859 |
DOI: |
10.1007/978-1-4899-1483-5_18 |
Popis: |
The e4 allele of apolipoprotein E (ApoE) has been associated with Alzheimer’s disease (AD): the frequency of the e4 allele is elevated in samples of AD patients1,2 and individuals with a single or double dose of the s4 allele have earlier onset of AD symptoms1. Furthermore, subjects with one or two e4 alleles have been shown to have increased amounts of the neurofibrillary tangles and amyloid plaques associated with AD3. |
Databáze: |
OpenAIRE |
Externí odkaz: |
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