Apolipoprotein E Genotype in Vascular Dementia

Autor: Giorgio Annoni, Ludovica Caputo, Jacopo Tagliabue, Carlo Vergani, Anthony Ryan
Rok vydání: 1998
Předmět:
Zdroj: Recent Advances in Geriatrics ISBN: 9781489914859
DOI: 10.1007/978-1-4899-1483-5_18
Popis: The e4 allele of apolipoprotein E (ApoE) has been associated with Alzheimer’s disease (AD): the frequency of the e4 allele is elevated in samples of AD patients1,2 and individuals with a single or double dose of the s4 allele have earlier onset of AD symptoms1. Furthermore, subjects with one or two e4 alleles have been shown to have increased amounts of the neurofibrillary tangles and amyloid plaques associated with AD3.
Databáze: OpenAIRE