Trihaloisocyanuric acids in ethanol: an eco-friendly system for the regioselective halogenation of imidazo-heteroarenes

Autor:	Fábio Z. Galetto, Antonio L. Braga, Renata A. Balaguez, Sumbal Saba, José S. S. Neto, Marcelo S. Franco, Jamal Rafique, Victor C. de Sá Machado
Rok vydání:	2020
Předmět:	Indazole chemistry.chemical_compound Ethanol chemistry Imidazothiazole Environmental Chemistry Halogenation Regioselectivity Pollution Combinatorial chemistry Environmentally friendly
Zdroj:	Green Chemistry. 22:3410-3415
ISSN:	1463-9270 1463-9262
DOI:	10.1039/d0gc00137f
Popis:	Herein, we describe an efficient, rapid and benign protocol for the direct C(sp2)–H bond halogenation (Cl, Br, I) of 2-arylimidazo[1,2-a]pyridines using trihaloisocyanuric acids in ethanol. Furthermore, this sustainable protocol was successfully extended to imidazopyrimidine, imidazothiazole and indazole heterocycles showing the broadness of this useful approach.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a44d040ac6fe43fc8c2838c107502a3d https://doi.org/10.1039/d0gc00137f Zobrazit plný text záznamu