Simultaneous determination of Ketorolac tromethamine and Fluorometholone in Eye drops by spectrophotometry
| Autor: | Malineni Sushmitha, Mukthinuthalapati Mathrusri Annapurna, Vellanki S. V. Sevyatha |
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| Rok vydání: | 2017 |
| Předmět: |
Chromatography
medicine.diagnostic_test Chemistry Ophthalmic preparations Phosphate buffered saline 02 engineering and technology 021001 nanoscience & nanotechnology 030226 pharmacology & pharmacy Ketorolac Tromethamine 03 medical and health sciences 0302 clinical medicine Ratio method Spectrophotometry Anesthesia medicine Pharmacology (medical) 0210 nano-technology Pharmacology Toxicology and Pharmaceutics (miscellaneous) Fluorometholone medicine.drug |
| Zdroj: | Research Journal of Pharmacy and Technology. 10:1179 |
| ISSN: | 0974-360X 0974-3618 |
| DOI: | 10.5958/0974-360x.2017.00225.6 |
| Popis: | Four simple spectrophotometric methods have been developed for the simultaneous determination of Fluorometholone and Ketorolac tromethamine in ophthalmic preparations. Simultaneous equation method, absorbance ratio method (Q – Analysis), first derivative method and multicomponent mode of analytical techniques were selected for the determination of Fluorometholone and Ketorolac tromethamine in phosphate buffer (pH 2.0) solution. Fluorometholone and Ketorolac tromethamine has followed linearity over the concentration range 0.1-20 µg/mL and 1-20 µg/mL respectively. The methods were validated and applied for the simultaneous determination of Fluorometholone and Ketorolac tromethamine in the available pharmaceutical formulations i.e. eye drops. |
| Databáze: | OpenAIRE |
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