Ocular herpes simplex virus infection is diminished by depletion of B lymphocytes
| Autor: | C Jordan, S Baron, F Dianzani, J Barber, G J Stanton |
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| Rok vydání: | 1983 |
| Předmět: | |
| Zdroj: | The Journal of Immunology. 131:1554-1557 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.131.3.1554 |
| Popis: | Rabbit anti-mouse mu-chain serum was used to deplete specifically IgM-bearing B cells and B cell function in BALB/c mice. B cell-depleted and normal littermates were infected via the cornea with herpes simplex virus type 1 (HSV-1) at 4 to 5 wk of age. B cell-depleted mice had a reduced number of lymphocytes bearing surface immunoglobulin and a greatly reduced ability to produce antibody. Mortality was reduced from 89% in normal controls to 42% in B cell-depleted mice (p less than 0.001) and peak virus shedding from eyes was also reduced as much as 90% in the B cell-depleted mice (p less than or equal to 0.0005). These results support the hypothesis that a B cell function of normal mice somehow contributes directly or indirectly to the enhanced mortality of mice infected with HSV. |
| Databáze: | OpenAIRE |
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