Cefepime-induced neurotoxicity after flap surgery: a rare case report

Autor:	Woo Jin Song, Chan Yeong Lee, Hyeong Rae Ryu, Je Yeon Byeon, Hwan Jun Choi
Rok vydání:	2023
Předmět:	General Earth and Planetary Sciences General Environmental Science
Zdroj:	Archives of Hand and Microsurgery. 28:63-66
ISSN:	2586-3533 2586-3290
DOI:	10.12790/ahm.22.0057
Popis:	Cefepime is a fourth-generation cephalosporin that covers gram-positive bacteria and gram-negative bacteria, such as Pseudomonas. A 48-year-old male patient underwent a posterior tibial artery perforator-based fasciocutaneous turnover flap and was administered cefepime. After 2 days, the patient showed neurological symptoms, such as cognitive decline and aphasia. We immediately stopped cefepime and changed to ciprofloxacin. In addition, thiamine was administered and additional dialysis was performed. The neurological symptoms were resolved after tapering cefepime and hemodialysis. In patients undergoing flap surgery, especially those with impaired renal function, cefepime should be administered carefully considering the risk of neurotoxicity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a42af07a0f92ad45e26c26603859534e https://doi.org/10.12790/ahm.22.0057 Zobrazit plný text záznamu Plný text ve formátu PDF