LIDOCAINE IN MICROEMULSION - A DERMAL DELIVERY SYSTEM
| Autor: | I. Blute, J. Carlfors, V. Schmidt |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Chromatography
Polymers and Plastics Lidocaine Chemistry Nuclear magnetic resonance spectroscopy Atmospheric temperature range Surfaces Coatings and Films Solvent chemistry.chemical_compound medicine Microemulsion Physical and Theoretical Chemistry Solubility Isopropyl myristate Phase inversion medicine.drug |
| Zdroj: | Journal of Dispersion Science and Technology. 12:467-482 |
| ISSN: | 1532-2351 0193-2691 |
| DOI: | 10.1080/01932699108913146 |
| Popis: | In order to obtain a microemulsion that is stable at skin temperature, the regions of existence of microemulsions of water and isopropyl myristate were studied as a function of hydrophile-lipophile balance (HLB) of nonionic surfactant mixtures. The microemulsion dissolves large amount of the local anaesthetic - lidocaine. The amount of dissolved lidocaine in the microemulsion was proportional to the isopropyl myristate content and limited to its solubility in this solvent. The addition of lidocaine lowered the phase inversion temperature (PIT) of the system and increased the temperature range for microemulsion stability. The structure of the microemulsion, as investigated by proton Fourier transform pulsed-gradient spin-echo NMR spectroscopy, was found to be bicontinous. The physico - chemical properties of the microemulsion as well as the low toxicity of its components result in formulation intendend for topical administration. |
| Databáze: | OpenAIRE |
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