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For various reasons, including drug availability, formulation bulk and toxicological considerations, it is important to use as little cyclodextrin (CD) as possible in pharmaceutical formulations. The complexation efficacy of CDs is generally rather low and, consequently, relatively large amount of CD has to be used to solubilize relatively small amount of drug. Thus, it is important to develop methods which enhance the complexation efficacy [1]. Furthermore, the aqueous solubility of the parent CDs and their complexes is low which limits their usage in pharmaceutical formulations. |
