Aerodigestive continuum: GERD and Barrett's esophagus in World Trade Center exposed firefighters
| Autor: | Sophia Kwon, Mohamed Zedan, Syed Hissam Haider, David J. Prezant, Anna Nolan, Liqun Zhang, Erin J. Caraher, Audrey K. Lee |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty education.field_of_study business.industry Medical record Insulin medicine.medical_treatment Incidence (epidemiology) Population World trade center Disease medicine.disease digestive system diseases humanities Surgery 03 medical and health sciences 030104 developmental biology Barrett's esophagus Internal medicine medicine GERD education business |
| Zdroj: | 6.2 Occupational and Environmental Health. |
| DOI: | 10.1183/13993003.congress-2016.pa4301 |
| Popis: | Background: World Trade Center (WTC) exposed firefighters developed aerodigestive disease. This pilot study focuses on identifying predictive biomarkers of GERD and Barrett9s in firefighters with WTC exposure. Methods: Retrospective analysis of electronic medical records identified those with incident GERD, Barrett9s and short-acting (SABA)/ long-acting beta-agonists (LABA) use in never smoking firefighters. Serum was analyzed on a subcohort (Luminex). Regression was used to identify the association of SABA/LABA and analytes that could predict GERD and/or Barrett9s. Results: Lung function (FEV 1 ) at the time of presentation was no different in those with GERD/Barrett9s compared to controls. After adjusting for age, BMI, and exposure, SABA use was a significant predictor of GERD, but not Barrett9s. C-peptide and Insulin predicted GERD as continuous variables. CRP, Fractalkine, G-CSF, Insulin, IP-10, and Triglyceride significantly predicted Barrett9s. Cutpoints were optimized in this population to determine clinically useful levels. Conclusion: Although there is an association between SABA use and GERD in this population, there is no increased incidence of Barrett9s. We demonstrate that metabolically active mediators, insulin and triglycerides, have a strong association with GERD and Barrett9s. This pilot study frames future studies to further our understanding of aerodigestive pathology due to particulate exposure. |
| Databáze: | OpenAIRE |
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