Copper deficiency fails to affect vitamin A status
| Autor: | John G. Bieri, J. Cecil Smith, Anne M. Dulin |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Vitamin
medicine.medical_specialty Nutrition and Dietetics medicine.diagnostic_test biology Nutrient interaction Endocrinology Diabetes and Metabolism Retinol Weanling Retinol Equivalent Hematocrit medicine.disease Superoxide dismutase chemistry.chemical_compound Endocrinology chemistry Internal medicine medicine biology.protein Copper deficiency |
| Zdroj: | Nutrition Research. 12:1365-1372 |
| ISSN: | 0271-5317 |
| DOI: | 10.1016/s0271-5317(05)80535-4 |
| Popis: | The effect of dietary copper (Cu) deficiency on vitamin A status as measured by serum and liver vitamin A was examined. Weanling male Sprague Dawley rats were randomly assigned by weight to one of four groups of 11–12 animals. Group 1 was fed a Cu deficient diet; Group 2, Cu supplemented, pair fed; Group 3 Cu supplemented, weight-matched to Group 1; Group 4 Cu supplemented, ad lib. All diets were supplemented with vitamin A (1,200 retinol equivalents/Kg). After six weeks, the animals were sacrificed and indices of Cu and vitamin A status measured. There was no significant difference for body weight gain or food intake among Groups 1, 2 and 3, eliminating these as variables. Copper deficiency was verified in Group 1 by significantly lowered hematocrit as well as lower serum, heart, and liver Cu concentrations. In addition, liver Cu−Zn superoxide dismutase (SOD) activity was significantly lowered, and cardiac hypertrophy was evident in the Cu deficient group. Serum and liver vitamin A concentrations did not differ significantly among all four groups. Total liver vitamin A content was not significantly different among the livers of rats fed the Cu deficient diet (Group 1), the Cu supplemented diet (pair-fed, Group 2) or Cu supplemented diet (weight-matched, Group 3). The results demonstrate that Cu deficiency does not affect vitamin A metabolism as assessed by serum and liver vitamin A concentrations, using rats as the model. |
| Databáze: | OpenAIRE |
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