| Autor: | Andreas Jessel, Wolf-Ulrich Nickel, John S. Schroeder, Bernard R. Chaitman, Thomas Meinertz, Harvey D. White, Leif Erhardt, James T. Willerson, Gianni Tognoni, Pierre Théroux |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
medicine.medical_specialty
Necrosis Cariporide business.industry Sodium Cell Ischemia chemistry.chemical_element Calcium Pharmacology medicine.disease Sodium–hydrogen antiporter chemistry.chemical_compound medicine.anatomical_structure chemistry Internal medicine Cardiology Medicine Myocyte medicine.symptom Cardiology and Cardiovascular Medicine business |
| Zdroj: | Current Controlled Trials in Cardiovascular Medicine. 1:059 |
| ISSN: | 1468-6708 |
| DOI: | 10.1186/cvm-1-1-059 |
| Popis: | Inhibition of the sodium‐hydrogen exchanger (NHE) is a powerful experimental tool to inhibit sodium and calcium accumulation within the ischemic myocyte and halt progression of cell ischemia to cell necrosis. This paper describes the protocol and rationale of a first largescale clinical trial designed to evaluate the safety and efficacy of cariporide, a novel specific and potent inhibitor of the exchanger. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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