Phenotypic variation in hereditary nonpolyposis colon cancer syndrome association with infiltrative fibromatosis (desmoid tumor)
| Autor: | Eamonn R. Maher, B. Morson, S. V. Hodgson, R. Beach |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
congenital
hereditary and neonatal diseases and abnormalities Cancer Research Fibromatosis desmoid Pathology medicine.medical_specialty business.industry Colorectal cancer Fibromatosis medicine.disease Hereditary Nonpolyposis Colon Cancer Phenotype digestive system diseases Familial adenomatous polyposis Oncology Medicine business neoplasms |
| Zdroj: | Cancer. 69:2049-2051 |
| ISSN: | 1097-0142 0008-543X |
| DOI: | 10.1002/1097-0142(19920415)69:8<2049::aid-cncr2820690807>3.0.co;2-6 |
| Popis: | Familial infiltrative fibromatosis (desmoid tumor) is a recognized complication of familial adenomatous polyposis (FAP) but has not been described in families without colonic polyposis. The authors describe a unique family in which a predisposition to infiltrative fibromatosis and nonpolyposis colon cancer was inherited dominantly through four generations. This report expands the range of phenotypic variation described for the hereditary nonpolyposis colon cancer (HNPCC) syndrome and adds to the extracolonic complications that are common with FAP and HNPCC. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text