Nickel-Catalyzed Cyanation of Unactivated Alkyl Chlorides or Bromides with Zn(CN)2
| Autor: | Chunli Zhang, Jidong Zhao, Aiyou Xia, Xin Xie, Haoyi Chen, Yuanhong Liu |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
chemistry.chemical_classification
010405 organic chemistry Cyanide Organic Chemistry chemistry.chemical_element Cyanation 010402 general chemistry 01 natural sciences Biochemistry Medicinal chemistry 0104 chemical sciences Catalysis Nickel chemistry.chemical_compound chemistry Nickel catalyst Physical and Theoretical Chemistry Alkyl |
| Zdroj: | Organic Letters. 20:7735-7739 |
| ISSN: | 1523-7052 1523-7060 |
| Popis: | A nickel-catalyzed cyanation of unactivated secondary alkyl chlorides or bromides using less toxic Zn(CN)2 as the cyanide source has been developed. The reaction features the use of air-stable and inexpensive NiCl2·6H2O or Ni(acac)2 as the precatalysts and offers an efficient synthesis of a broad range of alkyl nitriles. Cyanation of primary alkyl chlorides or bromides was also achieved by reaction with Zn(CN)2 in the presence of n-Bu4NCl without the need of nickel catalyst. |
| Databáze: | OpenAIRE |
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