Synthesis of vicinal (alkylamino)alkynylcyclopropanes from geminal alkynyl(chloro)cyclopropanes

Autor:	Konstantin N. Shavrin, Oleg M. Nefedov, Mikhail P. Egorov, Valentin D. Gvozdev
Rok vydání:	2021
Předmět:	Geminal Chemistry General Chemistry Alkylation Conjugated system Medicinal chemistry Vicinal
Zdroj:	Mendeleev Communications. 31:654-656
ISSN:	0959-9436
Popis:	New N-Boc-alkyl(2-alkynylcyclopropyl)amines were synthesized from 1-alkynyl-1-chlorocyclopropanes and N-Boc- alkylamines under the action of ButOK in DMSO, the intermediates having been the corresponding conjugated alkynylcyclopropenes. The Boc-derivatives can be converted into free secondary 2-alkynylcyclopropylamines, as well as ββ-lithiated with subsequent alkylation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a40de221227d5c50ffbc509f42273ba6 https://doi.org/10.1016/j.mencom.2021.09.020 Zobrazit plný text záznamu Full Text from ScienceDirect