Characterization of select members of the Taxane family using Raman spectroscopy

Autor:	Penelope Cipriani, Dor Ben-Amotz
Rok vydání:	2005
Předmět:	Taxane Analytical chemistry Characterization (materials science) chemistry.chemical_compound symbols.namesake chemistry Baccatin III Computational chemistry Ab initio quantum chemistry methods symbols General Materials Science Spectroscopy Raman spectroscopy Drop coating
Zdroj:	Journal of Raman Spectroscopy. 36:1052-1058
ISSN:	1097-4555 0377-0486
DOI:	10.1002/jrs.1405
Popis:	Experimentally derived Raman spectra of three members of the taxane family are presented and discussed. The taxoids investigated were docetaxel (Taxotere® ), baccatin III and cephalotaxine. These analytes were studied because of their potent antitumor capability or they are potential precursors for the synthesis of highly valuable pharmaceutical drugs. Drop coating deposition Raman (DCDR) spectroscopy is utilized in order to examine the vibrational wavenumbers of the powders and solutions, down to concentrations as low as 1 µM. Normal Raman modes of two of the three taxanes are confirmed by comparing experimental spectra with related literature and quantum mechanical ab initio calculations. Copyright © 2005 John Wiley & Sons, Ltd.
Databáze:	OpenAIRE
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