Histopathological frequency of feline hepatobiliary disease in the UK
| Autor: | T. Scase, W. A. Bayton, David J. Price, N. H. Bexfield, C. Westgarth |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Hepatitis medicine.medical_specialty 040301 veterinary sciences business.industry Hepatobiliary disease Retrospective cohort study 04 agricultural and veterinary sciences Odds ratio medicine.disease Gastroenterology Breed 0403 veterinary science 03 medical and health sciences 030104 developmental biology Internal medicine medicine Histopathology Clinical significance Portosystemic shunt Small Animals business |
| Zdroj: | Journal of Small Animal Practice. 59:404-410 |
| ISSN: | 0022-4510 |
| DOI: | 10.1111/jsap.12810 |
| Popis: | Objectives To determine the histopathological frequency of feline hepatobiliary diseases in the UK and to identify breed, age and gender predispositions to developing individual diseases. Methods Histopathology results from 1452 feline liver biopsies were assessed. A control population of microchipped cats was used for breed comparison. Data were retrospectively categorised into hepatobiliary diseases according to World Small Animal Veterinary Association standards. Odds ratios and 95% confidence intervals were calculated to determine breed predispositions to the 10 most frequent diseases. Gender and age distributions were also evaluated. Results The most frequent diseases based on histopathology were neutrophilic cholangitis (20·5%), reactive hepatitis (20·4%), reversible hepatocellular injury (8·4%), lymphocytic cholangitis (6·8%), biliary cysts (5·7%), acute hepatitis (5·6%), haematopoietic neoplasia (5·6%), hepatocellular neoplasia (4·9%), congenital portosystemic shunt (3·8%) and cholangiocellular neoplasia (3·1%). Some previously unreported breed and age predispositions were identified. Clinical significance This is the first study to document the histopathological frequency of hepatobiliary diseases in a large cohort of cats in the UK, as well as novel breed and age predispositions. These data may help increase the index of suspicion of a particular disease in the absence of a biopsy-confirmed diagnosis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text