Relative Potency of the Atropine-Like Effects of A New parasympatholytic Drug, Scopolamine-N-(Cyclopropy 1 Methyl) Bromide and Those of Hyoscine-N-Butyl Bromide

Autor:	Bertoli D, Barantani E, Mazzolari M, Vibelli C, Litta-Modignani R
Rok vydání:	1977
Předmět:	Drug business.industry media_common.quotation_subject General Medicine Pharmacology Crossover study Parasympatholytic chemistry.chemical_compound Atropine chemistry Bromide Pharmacodynamics medicine Bioassay Butyl bromide business media_common medicine.drug
Zdroj:	Current Medical Research and Opinion. 5:333-340
ISSN:	1473-4877 0300-7995
DOI:	10.1185/03007997709110189
Popis:	SummaryA Double-Blind Crossover Trial With A 4-Point Bioassay Was Carried Out In 8 Convalescent In-Patients To Study The Relative Potency Of Scopolamine-N-(Cyclopropyl Methyl) Bromide (Da 3177), A New parasympatholytic Drug, Administered At Doses Of 2.5 mg And 5 mg I.V., And Hyoscine-N-Butyl Bromide, Administered At Doses Of 10 mg And 20 mg I.V., In Producing Atropine-Like Effects. The Results Showed That The Effects On Heart Rate And Near Point Of Accommodation Were Slightly Less With Da 3177, While Its Effects On Salivary Secretion Were A Little Greater Than Those Of Hyoscine-N-Butyl Bromide. It Is Suggested That Study Of The Pharmacodynamic Effects Of parasympatholytic Drugs Is A Relatively Simple Way Of Predicting Which Doses Should Be Effective Spasmolytically.
Databáze:	OpenAIRE
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