Selenium Biomarkers and Their Relationship to Cardiovascular Risk Parameters in Obese Women

Autor: Bruna Emanuele Pereira Cardoso, Thaline Milany Silva Dias, Larissa Cristina Fontenelle, Jennifer Beatriz Silva Morais, Kyria Jayanne Climaco Cruz, Mickael Paiva Sousa, Thayanne Gabryelle Visgueira Sousa, Stéfany Rodrigues Sousa Melo, Loanne Rocha dos Santos, Gilberto Simeone Henriques, Francisco Erasmo Oliveira, Tamires da Cunha Soares, Dilina do Nascimento Marreiro
Rok vydání: 2023
DOI: 10.21203/rs.3.rs-2800191/v1
Popis: A cross-sectional study was carried out with 210 women divided into a case group (obese, n=84) and a control group (eutrophic, n=126). Body weight, height and waist circumference, hip and neck circumference were measured and the waist-hip ratio and conicity index were calculated. Selenium in plasma, erythrocytes and urine, erythrocyte GPx activity, lipid profile, Castelli I and II index, and systolic and diastolic blood pressure were evaluated. Mean dietary selenium intake (µg/kg/day) and plasma and erythrocyte concentrations were lower in the obese group compared to the healthy group (p0.05). There was a negative correlation between plasma selenium concentrations and total cholesterol, not HDL, LDL-c and systolic blood pressure. Urinary selenium correlated negatively with waist circumference, hip circumference and positively with neck circumference, total cholesterol, triacylglycerols, HDL-c, non-HDL and VLDL-c. There was a negative correlation between dietary selenium and waist circumference, waist-hip ratio, neck circumference, conicity index, non-HDL cholesterol, LDL-c, Castelli index I and II, as well as a positive correlation with HDL-c and diastolic blood pressure . Women with obesity present changes in their nutritional status related to selenium, as well as increased cardiovascular risk parameters. Thus, the positive role of selenium in protecting the risk of cardiovascular disease is likely.
Databáze: OpenAIRE