Synthesis, radiochromatography and biodistribution of99mTc-dimethylphosphinoethane (DMPE) complexes
| Autor: | R. Dudczak, M. Wagner-Löffler, E. Hruby, P. Angelberger |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Biodistribution
Ligand Chemistry Stereochemistry Health Toxicology and Mutagenesis Radiochemistry Public Health Environmental and Occupational Health Pollution High-performance liquid chromatography Analytical Chemistry Electrophoresis Nuclear Energy and Engineering Yield (chemistry) Radiology Nuclear Medicine and imaging Spectroscopy |
| Zdroj: | Journal of Radioanalytical and Nuclear Chemistry Articles. 89:409-421 |
| ISSN: | 1588-2780 0236-5731 |
| DOI: | 10.1007/bf02040605 |
| Popis: | The title complexes were prepared from no-carrier-added99mTc−TcO 4 − and the air-sensitive reducing ligand DMPE under argon in ethanol-water. At acidic pH [Tc(III)Cl2 dmpe2]+ was formed, while alkaline pH led to the formation of [Tc(I)dmpe3]+. About 150°C and at least 10−3M DMPE was needed to achieve over 95% yield in less than 1 hour, otherwise the [Tc(V)O2dmpe2]+ intermediate was present. Electrophoresis demonstrated the unit positive charge and reversed-phase ion-pair HPLC provided separation and identification of99mTc-products by direct comparison with known99Tc-complexes. In rats the99mTc-complexes were excreted by kidneys and liver and reached high heart/blood but only low heart/lung and heart/liver ratios. In dogs satisfactory myocardial scintigrams were obtained in spite of high liver activity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink