| Autor: | Leo A. J. M. Sliedregt, Martin K. Bijsterbosch, Theo J.C. Van Berkel, Erik A.L. Biessen, Remco L. A. de Vrueh, Erik T. Rump |
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| Rok vydání: | 1999 |
| Předmět: |
Pharmacology
biology Chemistry Organic Chemistry Pharmaceutical Science Prodrug biology.organism_classification In vitro medicine.anatomical_structure Biochemistry Hepadnaviridae In vivo Hepatocyte medicine Molecular Medicine Liberation Pharmacology (medical) Asialoglycoprotein receptor Drug carrier Biotechnology |
| Zdroj: | Pharmaceutical Research. 16:1179-1185 |
| ISSN: | 0724-8741 |
| DOI: | 10.1023/a:1018933126885 |
| Popis: | Purpose. 9-(2-Phosphonylmethoxyethyl)adenine (PMEA), a potent inhibitor of Hepatitis B virus replication, is in vivo hardly taken up by parenchymal liver cells (the site of infection). Our aim is to examine whether lactosylated reconstituted HDL (LacNeoHDL), a lipidic particle that is specifically internalized by parenchymal liver cells, is a suitable carrier for the selective delivery of PMEA to this cell type. |
| Databáze: | OpenAIRE |
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