| Autor: |
I. V. Rakhmanova, I. N. D’yakonova, D. S. Burmistrova, O. V. Kamkina, Yu. S. Ishanova |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Russian Otorhinolaryngology. 17 |
| ISSN: |
1810-4800 |
| Popis: |
The objective of the work is the comparative study of acoustic function of immature animals after subsequent injection of therapeutic doses of vancomycin and gentamycin (group 1) and vancomycin and amikacin (group 2). The general toxic effect was observed in the first group of animals. More expressed ototoxic effect, according to ABR and DPOAE, was observed in the second group of animals which manifested itself in a more significant rise of ABR 1st peak thresholds. The comparison of the central conduction time did not reveal any significant differences. The injection of vancomycin and gentamycin has resulted in the reduction of DPOAE evoked response at the frequencies of 4 kHz, and the injection of vancomycin and amikacin provided such reduction at the frequency of 6 kHz. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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