Some formulation factors influencing the rate of drug release from bioadhesiw matrices

Autor:	J. D. Smart
Rok vydání:	1992
Předmět:	Pharmacology Drug Chromatography Stereochemistry media_common.quotation_subject Bioadhesive Organic Chemistry Polyacrylic acid Kinetics Pharmaceutical Science Controlled release chemistry.chemical_compound chemistry Drug Discovery medicine Adhesive Lactose Swelling medicine.symptom media_common
Zdroj:	Drug Development and Industrial Pharmacy. 18:223-232
ISSN:	1520-5762 0363-9045
Popis:	The development of monolithic matrices with controlled release and mucosa-adhesive properties was investigated. After an initial screening procedure for formulations that showed stability and minimal swelling, the rate of release of a model water soluble drug from various polyacrylic acid containing matrices was evaluated. All the formulations gave a prolonged drug release relative to a lactose containing control formulation. A formulation containing Carbopol 934P and CaCl2, was found to give the slowest rate of drug release (t50% of 7.77h), with release kinetics nearest to the ideal zero order. When tested in a modified tensiometer it was found that the inclusion of a relatively high loading of a model drug did not adversely affect the adhesive properties of these formulations.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a3e5e5029556356fb0a7262f96c732d9 https://doi.org/10.3109/03639049209043695 Zobrazit plný text záznamu