Suppressive Effects of the Anti-al1ergic Drugs, Tranilast and Azelastine, on the Lysophosphatidylserine-Dependent Activation of Rat Mast Cells

Autor:	Ichiro Kudo, Keizo Inoue, Hidetada Komatsu, Kiyoto Hara, Arao Ujiie, Naoyuki Tsutsumi, Tetsuyuki Kobayashi, Shigeru Ikeda
Rok vydání:	1994
Předmět:	Pharmacology Tranilast Pharmaceutical Science Biological activity General Medicine Mast cell Azelastine In vitro chemistry.chemical_compound medicine.anatomical_structure chemistry Lysophosphatidylserine Immunology medicine Anti allergy Histamine medicine.drug
Zdroj:	Biological and Pharmaceutical Bulletin. 17:1121-1123
ISSN:	1347-5215 0918-6158
Popis:	Anti-allergic drugs, tranilast and azelastine, were examined for their effects on lysophosphatidylserine (lysoPS)-dependent histamine release from rat mast cells. Although both compounds suppressed the histamine release in a dose-dependent manner, the inhibition was affected by lysoPS concentration differently. In the presence of an increasing concentration of lysoPS, the suppressive effect of tranilast decreased. The inhibition by azelastine, however, was independent of the concentration of lysoPS. The findings suggest that these two drugs inhibit lysoPS-dependent histamine release through essentially different routes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a3e0cec86ffd0470c1be971ba18e15b1 https://doi.org/10.1248/bpb.17.1121 Zobrazit plný text záznamu