Drug Encapsulated Nanomaterials as Carriers Used in Cardiology Field
| Autor: | Letitia Doina Duceac, Constantin Marcu, Geta Mitrea, Alina Costina Luca, Lucian Eva, Alin Constantin Iordache, Irina Mihaela Ciomaga, Elena Roxana Bogdan Goroftei, Madalina Irina Ciuhodaru, Liviu Stafie, Elena Hanganu |
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| Rok vydání: | 2020 |
| Předmět: |
Drug
Process equipment Chemistry Materials Science (miscellaneous) Process Chemistry and Technology media_common.quotation_subject General Engineering Nanotechnology General Chemistry General Medicine General Biochemistry Genetics and Molecular Biology Nanomaterials Cardiology field Petrochemistry Materials Chemistry General Pharmacology Toxicology and Pharmaceutics media_common |
| Zdroj: | Revista de Chimie. 71:413-417 |
| ISSN: | 2668-8212 0034-7752 |
| Popis: | Pulmonary arterial hypertension is a disorder of high mortality being described by a progressive increase in pulmonary vascular strength leading to right ventricular damage and death. Endotelin-1 (ET-1) has an important pathogenic fuction in pulmonary hypertension. Bosentan is an oral ET-1 receptor antagonist that proved to be efficient at exercise tolerance in patients with pulmonary hypertension in functional class III and IV. The early trial registered for functional class II patients and evaluated hemodynamic at 6 month. Considerable side effects of bosentan comprise anemia, edema, and transaminase raise. Further studies were developed to determine optimum treatment strategy by eliminating adverse effects of bosentan. The major aim of this work was to prepare bosentan loaded nanoparticles by solvent evaporation technique for a sustained release of the drug by using ethyl cellulose as polymer. Drug and polymer were dissolved in ethanol at different drug-polymer ratios i.e. 1:2 and 1:3. Among the two formulations, 1:3 formulations were appreciated as the best formulation with better drug content (97.5%) and incorporation efficiency (95.5%). |
| Databáze: | OpenAIRE |
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