Dual functional hybrid-polyoxometalate as a new approach for multidrug delivery
| Autor: | Valiollah Mirkhani, Davud Karimian, Bahram Yadollahi |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Drug
010405 organic chemistry Chemistry media_common.quotation_subject Cancer therapy Nanoparticle Nanotechnology General Chemistry Mesoporous silica 010402 general chemistry Condensed Matter Physics 01 natural sciences 0104 chemical sciences Mechanics of Materials Drug delivery Polyoxometalate Cancer cell General Materials Science Drug carrier media_common |
| Zdroj: | Microporous and Mesoporous Materials. 247:23-30 |
| ISSN: | 1387-1811 |
| DOI: | 10.1016/j.micromeso.2017.03.048 |
| Popis: | Herein, a new antitumor active polyoxometalate, (TBA)4H3[GeW9V3O40], has been introduced as an inorganic drug with enormous influence on brain cancer cells and its outstanding results against U87 cells have been described. Post-functionalization of this polyoxometalate produces a drug delivery vehicle which comprises both kinds of inorganic and organic drugs. This system is consisted of mesoporous silica nanoparticles as organic drug carrier, along with redox-responsive disulfide bonds for drug release into the cell at the same time. Moreover, a fluorescence dye has been attached to the polyoxometalate that allows for tracking the drug into the cell environment. This dual-functionalized polyoxometalate was utilized in a designed multidrug delivery system, and worked greatly against U87 cells and knocked down these cancer cells up to near 70% in 48 h. Due to its unique properties, this multidrug delivery vehicle is potent to be developed and used for various applications in cancer therapy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect