| Autor: |
Saskia B. Ebeling, Anton Hagenbeek, Marina I. Garin, Ch. Ferrand, J. F. Apperley, K. F. Gaiser, David E. Chalmers, Elles R. Simonetti |
| Rok vydání: |
2003 |
| Předmět: |
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| Zdroj: |
Haematology and Blood Transfusion Hämatologie und Bluttransfusion ISBN: 9783642639494 |
| DOI: |
10.1007/978-3-642-59358-1_83 |
| Popis: |
Allogeneic stem cell transplantation involves infusion of hematopoietic stem cells from an HLA-matched donor together with T lymphocytes from the same donor. These donor T lymphocytes facilitate engraftment and may remove residual leukemic cells, which have survived the conditioning treatment [1]. This Graft-versus-leukemia (GvL) effect is often accompanied by graft-versus-host disease (GvHD) which may be life-threatening. Several approaches are being pursued in order to minimize GvHD while at the same time preserving or enhancing the GvL effect. Suicide gene therapy constitutes one of these approaches [2–8]. Prior to infusion into the patient, donor lymphocytes are genetically modified to express the Herpes Simplex Virus Thymidine Kinase (HSV-TK) gene. This allows specific elimination of those cells in vivo with ganciclovir (GCV), when GvHD symptoms become too severe. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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