Neuroanatomy of human appetitive function: A positron emission tomography investigation
| Autor: | Catherine M. Gordon, Nathaniel M. Alpert, A J Fischman, R. Lamm, Estherann Grace, Joseph A. Majzoub, Darin D. Dougherty, Scott L. Rauch, S. J. Emans |
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| Rok vydání: | 2000 |
| Předmět: |
Temporal cortex
media_common.quotation_subject digestive oral and skin physiology Appetite Paralimbic cortex medicine.disease Insular cortex Psychiatry and Mental health Eating disorders medicine.anatomical_structure Limbic system Laterality medicine Psychology Neuroscience media_common Neuroanatomy |
| Zdroj: | International Journal of Eating Disorders. 27:163-171 |
| ISSN: | 1098-108X 0276-3478 |
| Popis: | Objective The mediating neuroanatomy of human appetitive function is poorly understood. A state induction paradigm was employed, in conjunction with positron emission tomography, to test the hypothesis that limbic/paralimbic regions respond to the desirability of food stimuli. Methods Eight normal subjects were studied during each of three conditions, involving visual exposure to high-caloric food, low-caloric food, and nonfood stimuli. Subjective indices of hunger were measured via analog scales. Results Planned contrasts demonstrated significant increases in desire to eat and decreases in left temporoinsular cortical blood flow during the high-caloric versus control conditions. Discussion Results implicate the temporo-insular cortex in normal appetitive function, suggesting that activity within this region is associated with the desirability or valence of food stimuli, prior to ingestion. These data will provide a broad foundation for future studies of patients with eating disorders. © 2000 by John Wiley & Sons, Inc. Int J Eat Disord 27: 163–171, 2000. |
| Databáze: | OpenAIRE |
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