Properties of κ-carrageenan aerogels prepared by using different dissolution media and its application as drug delivery systems
| Autor: | Teresa Cordeiro, Carolina V. Pereira, Ana V.M. Nunes, Daniela A.S. Agostinho, Ana Matias, Isabel Fonseca, Ana I. Paninho, M. G. Ventura |
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| Rok vydání: | 2020 |
| Předmět: |
Aerogel
02 engineering and technology engineering.material 010402 general chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics 01 natural sciences Supercritical fluid 0104 chemical sciences Thermogravimetry chemistry.chemical_compound Differential scanning calorimetry chemistry Chemical engineering Ionic liquid Drug delivery engineering General Materials Science Biopolymer 0210 nano-technology Dissolution |
| Zdroj: | Materials Chemistry and Physics. 253:123290 |
| ISSN: | 0254-0584 |
| DOI: | 10.1016/j.matchemphys.2020.123290 |
| Popis: | This work reports the synthesis of kappa-carrageenan aerogels using different dissolution and crosslinking media in order to evaluate its effects on the textural properties of the matrixes and further on the drug loading and release performance. The different aerogel samples were produced through the dissolution of the biopolymer in water with addition of potassium salts as crosslinking agents and, in two different ionic liquids (ILs) derived from imidazolium ion, being further dried with supercritical CO2. The samples were characterized by Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy (ATR-FTIR), Scanning Electron Microscopy (SEM), Nitrogen Adsorption-Desorption Analysis, Thermogravimetry (TGA) and Differential Scanning Calorimetry (DSC). The synthesized samples presented surface areas similar to the carrageenan aerogels being their structure constituted mainly by meso and macropores. The absence of ionic liquid in samples was demonstrated by DSC analysis and was corroborated by the cytotoxicity assays which revealed that cellular viability in Caco-2 cells was preserved. Tetracycline was used as a model drug and loaded in two of the prepared aerogels samples. The release experiments were performed with the composites to test in vitro drug release at physiologic pH. With a higher macroporosity, the kappa-carrageenan aerogel prepared by dissolution into ionic liquid showed a higher loading capacity than the one prepared by dissolution into water and a slightly higher release rate. The matrixes were considered to present a good potential to be used as biocompatible carriers on drug controlled delivery. |
| Databáze: | OpenAIRE |
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