Amide-assisted α-C(sp3)–H acyloxyation of organic sulfides to access α-acyloxy sulfides
| Autor: | Zhi Li, Dai Shengfei, Xiaoqiang Sun, Ke Yang, Zhengyi Li |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
chemistry.chemical_classification
010405 organic chemistry Carboxylic acid Organic Chemistry Salt (chemistry) Substrate (chemistry) 010402 general chemistry 01 natural sciences Medicinal chemistry 0104 chemical sciences chemistry.chemical_compound chemistry Amide Functional group Surface modification Benzamide Selectfluor |
| Zdroj: | Organic Chemistry Frontiers. 8:4974-4979 |
| ISSN: | 2052-4129 |
| DOI: | 10.1039/d1qo00774b |
| Popis: | The direct acyloxyation of 2-(alkylthio)benzamide has been established via the amide-assisted α-C(sp3)–H functionalization in the presence of Selectfluor by employing simple carboxylic acid and its corresponding salt as acyloxy sources. This novel and simple method is characterized by its broad substrate scope in moderate to good yields and excellent functional group compatibility. Furthermore, this method also provides a complementary strategy to access important α-acyloxy sulfides and their derivatives. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|