Simultaneous Determination of Caffeine, Ibuprofen, and Paracetamol by Flow-injection Analysis with Multiple-pulse Amperometric Detection on Boron-doped Diamond Electrode

Autor:	Priscila N. C. Aguiar, Wallans T. P. dos Santos, Eduardo M. Richter, Flavio Santos Damos, Rita de Cássia Silva Luz, Eric de Souza Gil, Lívia M. F. C. Torres, Sandro C. Chaves, Rodrigo A.A. Munoz
Rok vydání:	2015
Předmět:	Boron doped diamond Flow injection analysis Chromatography Analytical chemistry Diamond engineering.material Ibuprofen Amperometry Analytical Chemistry chemistry.chemical_compound chemistry Electrode Electrochemistry medicine engineering Multiple pulse Caffeine medicine.drug
Zdroj:	Electroanalysis. 27:2785-2791
ISSN:	1040-0397
Popis:	This work presents a simple, fast and low-cost method for the simultaneous determination of three drugs by flow-injection analysis with multiple-pulse amperometric (MPA) detection using a wall-jet flow cell with a boron-doped diamond electrode. The amperometric determination of caffeine (CF), ibuprofen (IB) and paracetamol (PC) was performed by the application of a four-potential waveform using the MPA technique. PC is oxidized at E1 (1.20 V/70 ms) and thus selectively detected; PC and CF are oxidized at E2 (1.49 V/40 ms); PC, CF and IB are oxidized at E3 (1.70 V/70 ms); and E4 (1.80 V/100 ms) is applied for electrode cleaning. The subtraction of currents obtained at the different potentials did not provide accurate determinations of CF and IB, thus it was required to investigate correction factors to determine CF and IB without the interference from PC and CF using the respective amperometric signals obtained at E2 and E3. The proposed method was successfully applied for the determination of three drugs in pharmaceutical samples with low generation of residues and a high analytical frequency (150 h−1) in comparison with HPLC-DAD method.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a3bdc502cbfdaa6af80559b397e6e355 https://doi.org/10.1002/elan.201500306 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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