Tissue Distribution of Cocaine in a Pregnant Woman
| Autor: | Roger E. Mittleman, William Lee Hearn, Julio C. Cofino |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Kidney
Fetus medicine.medical_specialty Pregnancy Injury control Obstetrics business.industry Poison control Abortion medicine.disease Pathology and Forensic Medicine Surgery medicine.anatomical_structure embryonic structures Genetics medicine Tissue distribution medicine.symptom business reproductive and urinary physiology Vasoconstriction |
| Zdroj: | Journal of Forensic Sciences. 34:12662J |
| ISSN: | 0022-1198 |
| DOI: | 10.1520/jfs12662j |
| Popis: | Reports of cocaine-related obstetrical problems, including abruptio placentae and spontaneous abortion, have become increasingly evident in the medical literature; however, little is known about tissue distribution of cocaine in the pregnant woman. We report the toxicologic results of distribution studies performed on a pregnant woman and her fetus. Maternal/fetal cocaine concentration ratios were high when comparing blood (9:1), brain (6:5), and kidney (10:6). Possible explanations of the mechanism for lower fetal cocaine concentrations may include uterine vasoconstriction, incomplete maternal/fetal equalibration, or rapid placental/fetal clearance. Language: en |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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