Mixed Salts of Cobalt (II) with Ketoand Mercaptocarboxylic Acids – A Novel Potential Type of Antidote for Cyanides

Autor:	Yu. A. Davidovich, S. V. Kolbasov, M. V. Melikhova, V. D. Gladkikh, I. E. Chikunov, S. P. Nechiporenko, S. V. Kozlov, V. Yu. Kovtun
Rok vydání:	2021
Předmět:	Pharmacology medicine.medical_treatment Pharmacology toxicology chemistry.chemical_element chemistry.chemical_compound Cobalt salt chemistry Intragastric administration Drug Discovery medicine Antidote Cobalt Sodium cyanide Nuclear chemistry
Zdroj:	Pharmaceutical Chemistry Journal. 54:1136-1139
ISSN:	1573-9031 0091-150X
Popis:	We report here the synthesis of mixed salts of cobalt (II) with α-ketocarboxylic and mercaptocarboxylic acids, which have different types of antidote activity, in a single molecule. Simultaneous administration of the mixed cobalt salt with poison (sodium cyanide) at doses corresponding to the LD50 and LD99 ameliorated the main symptoms of poisoning by 75 – 100% and prevented death. The index of protection (IP) and antidote power (AP) on intragastric administration of compound 1a at a dose of 300 mg/kg immediately after sodium cyanide poisoning were 1.40 and 1.08 respectively. Prophylactic administration 30 min before poison increased these values 1.8-fold, giving IP = 2.5 and AP = 1.9.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a3b675375c124220533344c8945eecf6 https://doi.org/10.1007/s11094-021-02331-1 Zobrazit plný text záznamu Plný text ve formátu PDF