| Popis: |
A modern view of biological systems can be reduced to an understanding of an intricate network of protein interactions. In particular, structure-driven molecular interactions are responsible for biological function(s) at a cellular level. The post-genomic era has witnessed the emergence of improved and state-of-the-art technologies to characterize structure-function relationships. The emergence of these technologies has been further facilitated by faster computer processors, expanded memory, increased storage capacity, and newer algorithms. The need to obtain critical information on protein structures has resulted in significant improvements in methods such as protein crystallography and NMR (nuclear magnetic resonance). This chapter discusses advances in the structural evaluation of protein-protein interactions, epitope identification relative to biological function, as well as critical considerations for drug design and intellectual property protection. |
