Artificial model for cystathionine β-synthase: efficient β-replacement reaction with thiols employing a novel pyridoxal model compound having an imidazole function

Autor:	Hiroshi Iwaki, Takeshi Imanishi, Eito Yoshioka, Kazuyuki Miyashita, Hidenobu Murafuji
Rok vydání:	2003
Předmět:	biology ATP synthase Stereochemistry Organic Chemistry Cystathionine gamma-lyase Ionophore Biochemistry Cystathionine beta synthase chemistry.chemical_compound Residue (chemistry) chemistry Drug Discovery biology.protein Imidazole Pyridoxal Cysteine
Zdroj:	Tetrahedron. 59:4873-4879
ISSN:	0040-4020
Popis:	As a second-generation pyridoxal model compound for cystathionine β-synthase, we designed a novel model compound having an ionophore function and an imidazole function, application of which to the β-replacement reaction with various thiols smoothly took place to give S-substituted cysteines. Peptides having a serine-O-carbonate residue at the N-terminal position were also converted to the corresponding peptides having an S-substituted cysteine residue under the catalytic conditions of the novel pyridoxal model compound.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a3b2d54926703858807f245fe9970c9f https://doi.org/10.1016/s0040-4020(03)00666-5 Zobrazit plný text záznamu Full Text from ScienceDirect