| Popis: |
The hepatoprotective potential of hydro-alcoholic extract of Passiflora edulis leaves was evaluated against paracetamol and ethanol induced hepatotoxicity in rats. Two doses 200mg/kg and 400mg/kg, p.o of the extract were subjected for the evaluation of hepatoprotective potential against ethanol (2ml/100g) and PCM (2g/kg) induced liver injury. Silymarin (25mg/kg) was used as a standard drug. The parameters like SGPT, SGOT, ALP and Total Bilirubin (TB) were estimated to assess the liver functions. Liver antioxidant enzyme GSH was evaluated. In addition, histopathological study was also carried out. Both the doses of P. edulis extract showed dose dependent significant decrease of biochemical parameter such as ALP, SGOT, SGPT, TB and increased GSH level. Histopathology of liver showed reduced inflammation, centrilobular and bridging necrosis. It shows normal hepatocytes with significant reduction in areas of necrosis compared to toxic control. The result obtained was comparable with that of the standard drug Silymarin. The findings of the present study revealed that, hydro-alcoholic extract of Passiflora edulis might be beneficial against paracetamol and alcohol induced hepato toxicity. |
