First total synthesis of (+)-pentandranoic acid A

Autor:	Edward Piers, Li Ren
Rok vydání:	2012
Předmět:	chemistry.chemical_compound chemistry Stereochemistry Organic Chemistry Drug Discovery polycyclic compounds Total synthesis Alcohol Diterpenoid synthesis Biochemistry
Zdroj:	Tetrahedron Letters. 53:3329-3332
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2012.04.080
Popis:	The first total synthesis of (+)-pentandranoic acid A (1) was accomplished in 14 steps, starting from alcohol 3. Our synthesis features several key transformations, such as an ozonolysis-aldol cyclization-dehydration ring contraction sequence and a selective 1,4-diol oxidation, and provides an efficient synthetic route to this rare clerodane diterpenoid.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a38fd2d2dbd8ce95d21ad4b054333149 https://doi.org/10.1016/j.tetlet.2012.04.080 Zobrazit plný text záznamu Full Text from ScienceDirect