| Autor: |
Njideka Okubadejo, Olaitan Okunoye, Oluwadamilola Ojo, Babawale Arabambi, Rufus Akinyemi, Godwin Osaigbovo, Sani Abubakar, Emmanuel Iwuozo, Kolawole Wahab, Osigwe Agabi, Uchechi Agulanna, Frank Imarhiagbe, Oladunni Abiodun, Charles Achoru, Akintunde Adebowale, Olaleye Adeniji, John Akpekpe, Mohammed Alli, Ifeyinwa Ani-Osheku, Ohwotemu Arigbodi, Salisu Balarabe, Abiodun Bello, Oluchi Ekenze, Cyril Erameh, Temitope Farombi, Michael Fawale, Morenikeji Komolafe, Paul Nwani, Ernest Nwazor, Yakub Nyandaiti, Emmanuel Obehighe, Yahaya Obiabo, Olanike Odeniyi, Francis Odiase, Francis Ojini, Gerald Onwuegbuzie, Nosakhare Osemwegie, Olajumoke Oshinaike, Folajimi Otubogun, Shyngle Oyakhire, Funlola Taiwo, Uduak Williams, Simon Ozomma, Yusuf Zubair, David Curtis, Dena Hernandez, Sara Bandrés-Ciga, Cornelis Blauwendraat, Andrew Singleton, Henry Houlden, John Hardy, Mie Rizig |
| Rok vydání: |
2022 |
| Popis: |
The relationship between APOE polymorphisms and Parkinson’s disease (PD) in black Africans has not been previously investigated. We evaluated the association between APOE polymorphic variability and cognition in 1100 Nigerians with PD and 1097 matched healthy controls. Cognition in PD was assessed using the single item cognition question (item 1.1) of the MDS-UPDRS. APOE genotype and allele frequencies did not differ between PD and controls (p > 0.05). No allelic or genotypic association was observed between APOE and age at onset of PD. In PD, APOE ε4/ε4 conferred a two-fold risk of cognitive impairment compared to one or no ε4 (HR: 2.09 (95%CI: 1.13–3.89; p = 0.02)), while APOE ε2 was associated with modest protection against cognitive impairment (HR: 0.41 (95%CI 0.19–0.99, p = 0.02)). Altogether, our findings support previous studies in other ancestries, implying a role for APOE ε4 and ε2 as risk and protective factors respectively for cognitive decline in PD. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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