Molecular Imprinting-Chemiluminescence Sensor for the Determination of Amoxicillin
| Autor: | Yu Jinghua, Wan Fu-wei, Ge Shenguang, Dai Ping |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Detection limit
Chromatography Ethylene glycol dimethacrylate Biochemistry (medical) Clinical Biochemistry Biochemistry Analytical Chemistry law.invention Potassium permanganate chemistry.chemical_compound chemistry Methacrylic acid law Reagent Electrochemistry Molecular imprinting Ethylene glycol Spectroscopy Chemiluminescence |
| Zdroj: | Analytical Letters. 43:1033-1045 |
| ISSN: | 1532-236X 0003-2719 |
| DOI: | 10.1080/00032710903491104 |
| Popis: | The amoxicillin-imprinted polymer was synthesized with methacrylic acid (MAA) as a functional monomer and ethylene glycol dimethacrylate (EGDMA) as a cross-linker. The binding characteristic of the imprinted polymer to amoxicillin was evaluated by equilibrium binding experiments. Using the imprinted polymer as recognition material, 3-(3′-nitrophenyl)-5(2′-sulfonylphenylazo)-rhodanine (4NRASP) was synthesized by the authors and was used as chemiluminescence (CL) reagent. A novel chemiluminescence (CL) sensor for the determination of amoxicillin was developed based on the CL reaction of amoxicillin with potassium permanganate in an acidic medium. The sensor displayed excellent selectivity and high sensitivity. The linear response range of the sensor was from 5.0 × 10−9 to 1.0 × 10−6 g · mL−1 (r = 0.9985) and the detection limit was 1.3 × 10−9 g · mL−1. The relative standard deviation for the determination of 1.0 × 10−7 g · mL−1 amoxicillin solution was 1.7% (n = 11). The sensor was applied to the determinat... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |