Immune-Based Therapies for the Management of HIV Infection: Highly Active Antiretroviral Therapy and Beyond

Autor:	Aimee F. Ansari, Joseph V. Etzel
Rok vydání:	2000
Předmět:	Immune system business.industry Immunology Human immunodeficiency virus (HIV) Medicine Pharmacology (medical) business medicine.disease_cause Antiretroviral therapy
Zdroj:	Journal of Pharmacy Practice. 13:515-532
ISSN:	1531-1937 0897-1900
DOI:	10.1106/u537-l0gg-cd0j-qn0q
Popis:	The widespread use of highly active antiretroviral therapy (HAART) has had a significant impact on reducing the incidence of opportunistic infections in patients with the Acquired Immunodeficiency Syndrome (AIDS) and reducing the overall morbidity and mortality associated with this disease. However, the use of HAART is often associated with adverse effects, significant drug interactions, high cost and the emergence of viral resistance in a significant percentage of treatment recipients. In addition, the clinical efficacy of HAART in terms of viral eradication appears to be limited due to the presence of reservoirs of latent virus within HAART-experienced patients. Because of these and other limitations associated with antiretroviral therapies, new therapeutic strategies are being developed to restore the normal function of the immune system and improve patient outcomes. The purpose of this article is to review some of the more promising investigational immune-based therapies and their potential role in the management of Human Immunodeficiency Virus infection.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a3719f8685788ac8fef69188e85a95a2 https://doi.org/10.1106/u537-l0gg-cd0j-qn0q Zobrazit plný text záznamu