Electrochemical Stability of Poly(3,4-Ethylenedioxythiophene) Derivatives Under Cell Culture Conditions

Autor:	Qichao Pan, Yaqiong Zhang, Yaopeng Zhang, Bo Zhu, Zuwei Zhang
Rok vydání:	2021
Předmět:	History Bioelectronics Chemistry Adhesion Electrochemistry Computer Science Applications Education chemistry.chemical_compound Chemical engineering PEDOT:PSS Electrode Cell adhesion Biosensor Poly(3 4-ethylenedioxythiophene)
Zdroj:	Journal of Physics: Conference Series. 1885:032004
ISSN:	1742-6596 1742-6588
Popis:	Poly(3,4-ethylenedioxythiophene) (abbreviated as PEDOT) is widely used in nerve electrodes and biosensors. However, only a few investigations on the electrochemical stability of PEDOT derivatives in the biological environment have been reported. Here, the electrochemical performances of two PEDOT derivatives were evaluated during cell culture. The results showed phosphocholine-functionalized PEDOT (PEDOT-PC) to possess good anti-cell adhesion ability with 0.6% impedance change before and after cell culture. By comparison, hydroxyl-functionalized PEDOT (PEDOT-OH) promoted cell adhesion, in which impedance decreased by 17.6% with cell spreading due to strong adsorption of serum proteins. In sum, these findings look promising for the development of novel and facile PEDOT platforms for in vivo bioelectronics.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a362372d89c74e91dfdf58fd8e56ff86 https://doi.org/10.1088/1742-6596/1885/3/032004 Zobrazit plný text záznamu