Suppression of arterial intimal hyperplasia by cilostamide, a cyclic nucleotide phosphodiesterase 3 inhibitor, in a rat balloon double-injury model
| Autor: | Shirou Tochizawa, Kazuyuki Toga, Yoji Yoshida, Yoshihiro Inoue, Yukio Kimura, Kazue Tachibana, Hiroyoshi Hidaka, Toshiki Sudo |
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| Rok vydání: | 2000 |
| Předmět: |
Pharmacology
medicine.medical_specialty Intimal hyperplasia Vascular smooth muscle Cilostamide Cyclic nucleotide phosphodiesterase business.industry Phosphodiesterase 3 Phosphodiesterase Hyperplasia medicine.disease Tunica intima chemistry.chemical_compound Endocrinology medicine.anatomical_structure chemistry Internal medicine Medicine business |
| Zdroj: | British Journal of Pharmacology. 130:231-241 |
| ISSN: | 0007-1188 |
| DOI: | 10.1038/sj.bjp.0703287 |
| Popis: | The effects of cilostamide, a cyclic nucleotide phosphodiesterase 3 (PDE3) selective inhibitor, on vascular intimal hyperplasia were evaluated using a single-balloon injury model and a double-injury model in which the rat common carotid artery was subjected to a second injury at a site injured 14 days previously. In the double-injury model, the second balloon injury caused more severe intimal hyperplasia (intima/media (IM) ratio, 1.88+/-0.10) than in the single-injury model (1.09+/-0.08). Histopathological study revealed that vascular smooth muscle cells (VSMC) were the predominant cell-type in the affected neointimal area. Oral administration of cilostamide for 2 weeks after the second injury suppressed intimal hyperplasia in the double-injury model (30 mg kg(-1) bid, 83% inhibition in terms of the IM ratio, P |
| Databáze: | OpenAIRE |
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