Cytotoxic Activities of 9,10-seco-Cycloartane-Type Triterpenoids from the Chinese Liverwort Lepidozia reptans

Autor:	Lining Qian, Chun-Yang Zhang, Shu-Gong Liu, Jiao-Zhen Zhang, Hong-Xiang Lou, Jinchuan Zhou, Zhao-Jun Chu
Rok vydání:	2021
Předmět:	Pharmacology Programmed cell death Chemistry Stereochemistry Organic Chemistry Pharmaceutical Science Lepidozia reptans Analytical Chemistry Triterpenoid Complementary and alternative medicine Apoptosis Drug Discovery Ic50 values Molecular Medicine Cytotoxic T cell Moiety Bioassay
Zdroj:	Journal of Natural Products. 84:3020-3028
ISSN:	1520-6025 0163-3864
DOI:	10.1021/acs.jnatprod.1c00653
Popis:	Ten new triterpenoids, including nine 9,10-seco-cycloartanes (1-9) and one 9,19-cyclolanostane (10), as well as one sesquiterpenoid (11) and four known compounds (12-15), were extracted and purified from the whole plant of the Chinese liverwort Lepidozia reptans. Multiple techniques (NMR, HRESIMS, IR, and X-ray crystallographic analysis) were applied to determine the structures of the isolated compounds. Bioassay determinations showed that compound 7, which contains an α,β-unsaturated carbonyl moiety in its structure, inhibited the growth of a panel of cancer cell lines with IC50 values ranging from 4.2 ± 0.2 to 5.7 ± 0.5 μM. Further investigation revealed that compound 7 induces PC-3 cell death via mitochondrial-related apoptosis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a35c0c7b41ec8c27edd5887011f44e3b https://doi.org/10.1021/acs.jnatprod.1c00653 Zobrazit plný text záznamu