A Process for Active Pharmaceutical Ingredient Recovery from Tablets Using Green Engineering Technology
| Autor: | Mark Lindrud, Xujin Lu, Merrill L. Davies, Daniel S. Hsieh, Christopher A. Zordan, Liya Tang |
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| Rok vydání: | 2017 |
| Předmět: |
Active ingredient
Green engineering Materials science 010405 organic chemistry business.industry Process (engineering) Organic Chemistry Reuse bacterial infections and mycoses equipment and supplies 010402 general chemistry 01 natural sciences 0104 chemical sciences Diafiltration fluids and secretions bacteria Separation method Physical and Theoretical Chemistry Solubility Process engineering business Reverse osmosis |
| Zdroj: | Organic Process Research & Development. 21:1272-1285 |
| ISSN: | 1520-586X 1083-6160 |
| DOI: | 10.1021/acs.oprd.7b00146 |
| Popis: | The objective of this study is to recover Active Pharmaceutical Ingredients (APIs) from tablets via green engineering technology to meet material requirements for downstream formulation development. A separation train, using water as the separation media, includes dissolution, centrifugal phase separation, diafiltration and reverse osmosis and has been developed based on the physical properties of the API and excipients. These properties include solubility, multiphase behaviors, particle densities, and size differences between API and excipients. The recovered API both meets purity specifications and contains no polymer. It is suitable for reuse in formulation process development. The recovery of the API from tablets is over 90%. A green engineering technology using water and separation methods is successfully developed and used to recover API from tablets. |
| Databáze: | OpenAIRE |
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